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M9490016.TXT
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1994-09-03
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Document 0016
DOCN M9490016
TI The resurgence of tuberculosis.
DT 9411
AU Young LS; Wormser GP; Kuzell Institute for Arthritis and Infectious
Diseases,; California Pacific Medical Center, San Francisco 94115.
SO Scand J Infect Dis Suppl. 1994;93:9-19. Unique Identifier : AIDSLINE
MED/94323730
AB The resurgence of tuberculosis has been documented in both developed and
developing countries and is associated with the spread of human
immunodeficiency virus (HIV) infection. In the USA, the steady decline
in the incidence of tuberculosis witnessed during the past three decades
has halted, and since early 1986, a resurgence of tuberculosis has been
noted. A similar change in trend has occurred in the West, for example
Britain and continental Europe. The present problem is aggravated by the
emergence of multiply drug resistant (MDR) strains of Mycobacterium
tuberculosis. While drug resistance is not a new phenomenon, it had not
hitherto been experienced in combination with HIV infection. Previously,
MDR tuberculosis was indolent, slowly progressive and usually restricted
to the lungs. However, in the setting of an HIV-infected patient it is
often systemic, aggressive, difficult to treat and associated with early
mortality. In New York State, many of the population 'at risk' of
contracting tuberculosis, as well as of HIV infection have been
incarcerated. This provides a public health opportunity to intervene to
prevent and treat both of these diseases.
DE Antitubercular Agents/THERAPEUTIC USE Human HIV
Infections/COMPLICATIONS Prevalence Prisons/STATISTICS & NUMER DATA
*Tuberculosis, Multidrug-Resistant/COMPLICATIONS/DRUG THERAPY/
EPIDEMIOLOGY World Health JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).